Various pharmacological agents with a secretagogue effect can stimulate watery secretion, mucus secretion, or both.

Secretagogues Eye Drops

These can be considered in patients who require an increase in tear mucus or aqueous tear.

1. Diquafosol 3%
   • Dosage: Ideally used 5 to 6 times a day, reaching maximal effects in 1 to 3 months.
   • Adverse reactions: Eye discharge, eye irritation, and eye pain; nevertheless the dry eye symptoms remitted after 28 days.

Oral Medications

1. Cholinergic agonists
   • Pilocarpine and Cevimeline
   • They have FDA-approved indications for the treatment of dry mouth associated with Sjögren’s syndrome [REF][REF]

<aside> 💡 It is important to note that treatments outlined below should still be used in conjunction with those outlined in Dry Eye Treatment Starts Here!

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